Blockade of Interleukin 10 Potentiates Antitumour Immune Function in Human Colorectal Cancer Liver Metastases

Investigators created organotypic slice cultures from human colorectal cancer liver metastases and tested the antitumor effects of a neutralising antibody against IL-10 both alone as treatment and in combination with exogenously administered carcinoembryonic antigen-specific CAR-T cells.