Myeloid Cell Tropism Enables MHC-E–Restricted CD8⁺ T Cell Priming and Vaccine Efficacy by the RhCMV/SIV Vaccine

Using host microRNA-mediated vector tropism restriction, scientists showed that the priming of major histocompatibility complex (MHC)-II and MHC-E epitope–targeted responses depended on vector infection of different nonoverlapping cell types in rhesus macaques.