Newsletters

[Nature Biotechnology] Scientists explored variability in hPSC differentiation potential and the underlying epigenetic processes through the lens of epiblast anterior-posterior regionalization in vivo.

[Nature Neuroscience] Investigators developed a hiPSC-based three-dimensional cortical brain tissue model containing neurons, astrocytes, and microglia with high reproducibility, maturity and viability.

[Cell Reports] The authors reported that H2BK5ac regulates the acquisition of inflammatory potential in mouse ESCs during differentiation.

[EMBO Reports] Researchers showed that C-terminal binding protein 1/2 (CtBP1/2) restricts both DUX-dependent and independent 2-cell-like transcriptional programs in mESCs.

[Stem Cell Reports] The authors showed that pre-differentiation culture medium impacts the developmental potential of iPSCs, with StemFit medium and Matrigel embedding outperforming mTeSR Plus medium in generating robust somite-like structures.

[Communications Biology] Using an unbiased proteomic approach, scientists discovered that Trim28, along with subunits of various chromatin remodeling complexes and modifiers, interacts with Type II topoisomerase α (Top2a) on ESC chromatin.

[Trends in Cell Biology] Investigators summarize recent advances in our understanding of the role of the microtubule cytoskeleton in pluripotency maintenance.

[Sumitomo Pharma] Sumitomo Pharma America, Inc. announced that the first patient in its study evaluating DSP-3077 in the treatment of non-syndromic retinitis pigmentosa has undergone subretinal implantation. DSP-3077 is an investigative regenerative cell therapy that leverages allogeneic retinal sheets derived from iPSCs.

[Nature Chemical Biology] Researchers identified PRC2 inhibitors as potent inducers of β cell-enriched gene expression in α cells, acting through modulation of the AR–ETV1 complex.

[Diabetes] Investigators showed that adipose tissue palmitoylation cycling helps preserve pancreatic β-cell function and insulin secretion despite sustained insulin resistance.

[Signal Transduction and Targeted Therapy] The authors investigated the role of methyltransferase 3-mediated RNA methylation in pancreatic acinar cell carcinoma development and progression.

[Cancer Research] Scientists demonstrated that the αv integrin and neuropilin-1 dual targeting iRGD peptide reverses some of these tumor microenvironment features by inhibiting transforming growth factor β (TGFβ) activation in the tumor, a process mediated by the αvβ5 integrin.