Inhibition of Nucleoporin 214 Depletes Leukemia Stem Cells by Promoting Heme Catabolism and Lipid Peroxidation

By screening the nucleoporin (NUP) family, scientists identified NUP214 as a frequently overexpressed gene and a critical fitness determinant in leukemia stem cells (LSCs). NUP214 acts as a conserved driver of LSC survival by restricting heme catabolism, limiting Fe²⁺ accumulation, and suppressing lipid peroxidation.