Spatiotemporal Analysis of Glioma Heterogeneity Reveals COL1A1 as an Actionable Target to Disrupt Tumor Progression

The authors reported that Inhibition of Col1a1 eliminated oncostreams, reprogramed the malignant histopathological phenotype, reduced expression of the mesenchymal associated genes, induced changes in the tumor microenvironment, and prolonged animal survival.