Modulating T Cell Activation with Antisense Oligonucleotides Targeting Lymphocyte Cytosolic Protein 2

The authors identified a set of 3′ UTR targeting lymphocyte cytosolic protein 2 (LCP2) antisense oligonucleotides, which knocked down LCP2 in a human T cell line and primary human T cells and found that these suppressed T cell receptor mediated activation.