Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis

The authors studied synovial biopsies captured from untreated rheumatoid arthritis patients at time of diagnosis, and found that the tissue architecture implicated both local B cell maturation via T cell help and plasma cell survival niches with a strong CXCL12–CXCR4 axis.