Single Cell Sequencing Identifies Clonally Expanded Synovial CD4⁺ T_PH Cells Expressing GPR56 in Rheumatoid Arthritis

Researchers performed single cell sequencing on synovial CD4+ T cells from anti-citrullinated protein antibodies (ACPA)+ and ACPA- rheumatoid arthritis patients and identified two peripheral helper T cell (TPH) states and a cytotoxic CD4+ T cell subset.