Inhibition of Cell Invasion and Migration by Targeting Matrix Metalloproteinase-9 Expression via Sirtuin 6 Silencing in Human Breast Cancer Cells

Scientists investigated the effects of sirtuin 6 (SIRT6) on protein kinase C activator- and cytokine-mediated cancer cell invasion and migration in MCF-7 and MDA-MB-231 cells and the association between SIRT6 and matrix metalloproteinase-9 expression.