ROR1-Targeting Switchable CAR-T Cells for Cancer Therapy

To explore the therapeutic utility of switchable CAR-Ts targeting the receptor tyrosine kinase ROR1 and to identify bispecific adaptor proteins that efficiently mediated universal CAR-T engagement, a panel of switches based on ROR1-targeting Fabs with different epitopes and affinities was compared in in vitro and in vivo models of ROR1-expressing cancers.