Intranasal Vaccination with Lipid-Conjugated Immunogens Promotes Antigen Transmucosal Uptake to Drive Mucosal and Systemic Immunity

Researchers demonstrated a strategy of “albumin hitchhiking” to promote mucosal immunity using an intranasal vaccine consisting of protein immunogens modified with an amphiphilic albumin-binding polymer-lipid tail, forming amph-proteins.