In Vitro Airway Models From Mice, Rhesus Macaques, and Humans Maintain Species Differences in Xenobiotic Metabolism and Cellular Responses to Naphthalene

Researchers evaluated xenobiotic metabolism maintenance within differentiated air-liquid interface airway epithelial cell cultures, isolated airway epithelial cells, and ex vivo microdissected airways by measuring gene expression, glutathione content, and naphthalene metabolism.