A Clade C HIV-1 Vaccine Protects against Heterologous SHIV Infection by Modulating IgG Glycosylation and T Helper Response in Macaques

The authors developed a clade C HIV-1 vaccine consisting of priming with modified vaccinia Ankara and boosting with cyclically permuted trimeric gp120 protein, delivered either orally using a needle-free injector or through parenteral injection.