Distinct Sensitivities to SARS-CoV-2 Variants in Vaccinated Humans and Mice

Researchers reported that vaccinated BALB/c mice did not recapitulate faithfully the breadth and potency of neutralizing antibody responses elicited by various vaccine platforms against variants of concern, as compared to non-human primates or humans, suggesting caution should be exercised when interpreting data obtained with this animal model.