Newsletters

[Advanced Healthcare Materials] Researchers developed an in vitro cardiac inflammation model that enables controlled investigation of macrophage-cardiomyocyte interactions.

[European Journal of Pharmacology] Investigators demonstrated that empagliflozin reduced the incidence of ventricular arrhythmia by regulating AMPK/mTOR signaling and restored autophagic flux in DOX-treated rats and neonatal rat ventricular cardiomyocytes.

[Journal of Clinical Investigation] Scientists developed mice with myofiber-specific knockouts of prolyl hydroxylase proteins, in which HIFα is stabilized, and inducible myofiber-specific overexpression of stable HIF1α or HIF2α to explore the role of HIFα in myofibers.

[Elife] Using adult mouse skeletal muscles, the authors show that Scx expression is not detectable in adult muscle stem cells during quiescence.

[Scientific Reports] Researchers demonstrated a computational framework that offers a flexible and physiologically grounded tool for investigating the mechanisms of arrhythmogenesis in human-induced pluripotent stem cell-derived cardiomyocytes and for supporting personalized medicine applications.

[Acta Pharmacologica Sinica] The authors investigated the role of G9a in promoting vascular smooth muscle cell proliferation and vascular intimal hyperplasia and the underlying mechanisms.

[Life Sciences] Human aortic vascular smooth muscle cells were used to investigate UAMC-3203's mechanism.

[Communications Biology] Scientists found that Wnt11 is significantly up-regulated in the rat fibrotic bladders induced by bilateral pelvic nerve injury and spinal cord injury, and promotes bladder fibroblasts-to-myofibroblasts transition and smooth muscle cells phenotypic transformation.

[Journal of Neuromuscular Diseases] The authors explore the pathophysiology of satellite cell-opathies, highlighting key molecular mechanisms underlying their dysfunction.

[Solid Biosciences, Inc.] Solid Biosciences, Inc. announced a positive regulatory update from its recent Type C meeting with the US FDA that supports the continued advancement of SGT-003 as a potential treatment for Duchenne muscular dystrophy.

[Cell] Researchers generated a time-series endothelial resource covering the entirety of mouse embryonic development, including 26 time points and 8 organs.

[Journal of Clinical Investigation] 8803, a potent STING pathway agonist, combined with radiation therapy triggers distinctive antiglioma immune reactivity, facilitates blood-brain barrier opening, and warrants consideration for up-front clinical trials in glioblastoma, where treatment effects can be monitored using [18F]-FLT PET imaging.