Engineering of Hybrid Spheroids of Mesenchymal Stem Cells and Drug Depots for Immunomodulating Effect in Islet Xenotransplantation

Researchers engineered hybrid spheroids of mesenchymal stem cells with rapamycin-releasing poly(lactic-co-glycolic acid) microparticles to prevent immune rejection of islet xenografts in diabetic C57BL/6 mice.