CK2-Induced Cooperation of HHEX with the YAP-TEAD4 Complex Promotes Colorectal Tumorigenesis

Hematopoietically expressed homeobox (HHEX) was required for the pro-tumorigenic effects of yes-associated protein (YAP) during colorectal cancer progression. In response to serum stimulation, Casein Kinase 2 (CK2) phosphorylated HHEX and enhanced its interaction with TEAD4.