Combinatorial Treatment with Statins and Niclosamide Prevents CRC Dissemination by Unhinging the MACC1-β-Catenin-S100A4 Axis of Metastasis

Metastasis-associated in colorectal cancer-1 (MACC1) strengthened the interaction of β-catenin with TCF4, thus inducing S100A4 synthesis transcriptionally, resulting in elevated secretion to enforce cell motility and metastasis.