Tumor Microenvironment-Responsive Cu/CaCO₃-Based Nanoregulator for Mitochondrial Homeostasis Disruption-Enhanced Chemodynamic/Sonodynamic Therapy

Intelligent copper-dropped calcium carbonate (Cu/CaCO3) loading sonosensitizer Ce6 nanoparticles were established to realize tumor microenvironment-responsive self-supply of oxygen and successively Ca2+-overloading-strengthened chemodynamic therapy/sonodynamic therapy.