Exploring the Mechanistic Link between SF3B1 Mutation and Ring Sideroblast Formation in Myelodysplastic Syndrome

SF3B1K700E expressing cells showed higher proportion of ring sideroblasts (RS) than the control cells along with erythroid differentiation, indicating the direct contribution of mutant splicing factor 3b subunit 1 (SF3B1) expression in erythroblasts to RS formation.