Tackling Recalcitrant Pseudomonas aeruginosa Infections in Critical Illness via Anti-Virulence Monotherapy

Investigators showed that MvfR promoted intestinal permeability and reported potent anti-MvfR compounds, the N-Aryl Malonamides, resulting from extensive structure-activity-relationship studies and thorough assessment of the inhibition of MvfR-controlled virulence functions.