Newsletters

[Allergy] The authors investigated the molecular and functional consequences of sodium dodecyl sulfate and cocamidopropyl betaine exposure in primary eosinophilic esophagitis-derived esophageal organoids and air-liquid interface cultures derived from biopsy tissue samples.

[Cell Proliferation] Using patient-derived vascularised lung organoid, scientists demonstrated that cigarette smoke extract induces pathological features resembling clinical chronic obstructive pulmonary disease, including epithelial disruption and inflammatory responses.

[Communications Biology] Researchers developed SWIFT, Single-organoid Workflow for quantitative Imaging classiFication and Tracking, a fast and modular pipeline for quantitative, time-resolved organoid analysis from brightfield images.

[Cancer Chemotherapy and Pharmacology] Patient-derived breast cancer organoids were used to examine trastuzumab-associated ferroptosis-related changes and the possible involvement of p53 signaling.

[Molecular Psychiatry] The authors highlight the integration of brain organoids and AI as an emerging “organoid intelligence” approach to uncover autism biology and advance personalized therapeutic discovery.

[Greenstone Biosciences (Business Wire)] Greenstone Biosciences has been awarded a Breakthrough T1D Industry Discovery and Development Partnership grant to develop a T1D-derived islet cell platform aimed at understanding and protecting insulin-producing β cells in people with type 1 diabetes.

[Signal Transduction and Targeted Therapy] The authors identified SUMOylation as a specific, druggable regulator of RAC1-driven breast cancer metastasis using genetic mouse models and patient-derived organoids.

[Advanced Science] Researchers uncovered a cancer-associated fibroblast-exosomal circFAD104 axis that reprograms glucose metabolism to drive TNBC progression.

[Advanced Science] Scientists identified an enhancer-driven transcriptional program that promotes breast cancer metastasis under nutrient deprivation.

[Cell Reports Medicine] Investigators identified non-canonical functions of the extracellular matrix remodeler, lysyl oxidase (LOX), and showed that inhibiting LOX generates targetable vulnerability to ferroptosis in TNBC.

[Science Advances] The authors showed that methylscape, a cancer-specific DNA methylation landscape, can be leveraged to monitor cancer progression.

[EMBO Journal] Investigators combined CRISPRi-mediated ZSWIM8 depletion, miRNA-seq, and AGO2-eCLIP to define the target-directed microRNA degradation landscape across breast cancer subtypes.