Microglial TYROBP/DAP12 in Alzheimer’s Disease: Transduction of Physiological and Pathological Signals Across TREM2

In addition to reviewing the structure and localization of TYROBP, the authors discuss their recent progress using mouse models of either cerebral amyloidosis or tauopathy that were engineered to be TYROBP-deficient or TYROBP-overexpressing.