Review

[Blood] The authors discuss the current molecular landscape and functional characterization of three of the most lethal childhood AML fusion-oncogene driven subtypes harboring KMT2A, NUP98, or CBFA2T3::GLIS2 rearrangements.

[Journal of Hematology & Oncology] The authors scrutinize the key players in the tumor microenvironment (TME) and the TME's contribution to epithelial-mesenchymal transition, emphasizing avenues to therapeutically disrupt the interactions between the various TME components.

Bmi-1 regulates self-renewal, proliferation, and differentiation of GBM cells, promoting stemness and therapy resistance. The authors discuss the importance of targeting Bmi-1 which could be a promising therapeutic target for glioblastoma...

[Alzheimers & Dementia] Scientists conduct a comparative analysis of gene expression in endothelial cells and pericytes across neurodegenerative conditions utilizing transcriptomic data from published postmortem human tissue studies.

[Vascular Pharmacology] The authors discuss the impact of key and emerging molecular pathways that transduce aberrant inflammatory signals, oxidative stress, and mitochondrial dysfunction in aging vascular compartment.

[Journal of Translational Medicine] Investigators address the limitations and ongoing challenges within current research, offering insights that could guide the clinical application of bone marrow-derived mesenchymal stem cell-exosomes in the treatment of rotator cuff injuries in the future.