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Biological Relevance of Alternative Splicing in Hematologic Malignancies

[Molecular Medicine] Investigators provide an extensive overview of the biological relevance of aberrant isoforms of genes involved in the regulation of apoptosis, activation of key cellular signaling pathways, and cell metabolism.

Unveiling Heterogeneity in MSCs: Exploring Marker-Based Strategies for Defining MSC Subpopulations

[Journal of Translational Medicine] Scientists discuss the reported markers of MSCs, encompassing those developed through candidate marker strategies and high-throughput approaches.

The Integrated Stress Response in Pancreatic Development, Tissue Homeostasis, and Cancer

[Gastroenterology] Scientists review what is known about the key roles that the integrated stress response (ISR) plays in the development, homeostasis, and neoplasia of the pancreas.

Ferroptosis Exacerbates Hyperlipidemic Acute Pancreatitis by Enhancing Lipid Peroxidation and Modulating the Immune Microenvironment

[Cell Death Discovery] The authors focus on the malignant development of hyperlipidemic pancreatitis with severe disease combined with the core features of ferroptosis to explore and describe the mechanism of this phenomenon and show that the activation of lipid peroxidation and the aberrant intracellular release of many inflammatory mediators during ferroptosis are the key processes that regulate the degree of disease development in patients with hyperlipidemic acute pancreatitis.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] The authors present how arming Vδ2-T cells might be the basis for next-generation immunotherapies against solid tumors. Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, we will discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.

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