Interleukin-11 Signaling Underlies Fibrosis, Parenchymal Dysfunction, and Chronic Inflammation of the Airway

Initially thought of as a protective cytokine, interleukin-11 is now increasingly recognized as an important determinant of lung fibrosis, inflammation, and epithelial dysfunction.
[Experimental and Molecular Medicine]
Ng, B., Cook, S. A., & Schafer, S. (2020). Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway. Experimental & Molecular Medicine, 1–8. https://doi.org/10.1038/s12276-020-00531-5 Cite
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The Role of Natural Killer Cell in Gastrointestinal Cancer: Killer or Helper

The authors discuss natural killer cells’ cytotoxicity and modulation function in gastrointestinal cancer and the current application in clinical therapy.
[Oncogene]
Wang, F., Lau, J. K. C., & Yu, J. (2020). The role of natural killer cell in gastrointestinal cancer: killer or helper. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01561-z Cite
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The Many Lives of Myc in the Pancreatic β-Cell

The authors summarize the previous and recent knowledge of Myc in the β-cell, its potential for β-cell regeneration and its physiological importance for neonatal and adaptive β-cell expansion.
[Journal of Biological Chemistry]
Rosselot, C., Baumel-Alterzon, S., Li, Y., Brill, G., Lambertini, L., Katz, L. S., Lu, G., García-Ocaña, A., & Scott, D. K. (2020). The Many Lives of Myc in the Pancreatic β-Cell. Journal of Biological Chemistry, jbc.REV120.011149. https://doi.org/10.1074/jbc.REV120.011149 Cite
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Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity

Mitochondrial inhibition may be a viable strategy for eradicating cancer stem cells. Medicinal chemistry research over the last decade has synthesized and characterized “vehicles” capable of transporting novel or existing pharmacophores to mitochondrial tumor cells, based on mechanisms that exploit the physicochemical properties of the vehicles and the inherent properties of the mitochondria.
[International Journal of Molecular Sciences]
Catalán, M., Olmedo, I., Faúndez, J., & Jara, J. A. (2020). Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity. International Journal of Molecular Sciences, 21(22), 8684. https://doi.org/10.3390/ijms21228684 Cite
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The Clinical Role of the Gut Microbiome and Fecal Microbiota Transplantation in Allogeneic Stem Cell Transplantation

The authors define the role of administrating fecal microbiota transplantation in the setting of allogeneic hematopoietic stem cell transplantation.
[Haematologica]
Henig, I., Yehudai-Ofir, D., & Zuckerman, T. (2020). The clinical role of the gut microbiome and fecal microbiota transplantation in allogeneic stem cell transplantation. Haematologica. https://doi.org/10.3324/haematol.2020.247395 Cite
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Novel Human Immunomodulatory T Cell Receptors and Their Double-Edged Potential in Autoimmunity, Cardiovascular Disease and Cancer

Scientists discuss the roles of immunomodulatory receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases.
[Cellular & Molecular Immunology]
Martín, P., Blanco-Domínguez, R., & Sánchez-Díaz, R. (2020). Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer. Cellular & Molecular Immunology, 1–17. https://doi.org/10.1038/s41423-020-00586-4 Cite
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Detection of Immunogenic Cell Death and Its Relevance for Cancer Therapy

Scientists outline methodological approaches for measuring immunogenic cell death markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer regimens, and the identification of optimal therapeutic combinations for the clinical management of cancer.
[Cell Death & Disease]
Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020). Detection of immunogenic cell death and its relevance for cancer therapy. Cell Death & Disease, 11(11), 1–13. https://doi.org/10.1038/s41419-020-03221-2 Cite
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The Central Role of the Nasal Microenvironment in the Transmission, Modulation, and Clinical Progression of SARS-CoV-2 Infection

Scientists review the latest molecular and cellular findings on the mucosal response to SARS-CoV-2 in the nasal cavity and in Nasopharynx-Associated Lymphoid Tissue, and to analyze its impact in the subsequent course of COVID-19.
[Mucosal Immunology]
Gallo, O., Locatello, L. G., Mazzoni, A., Novelli, L., & Annunziato, F. (2020). The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection. Mucosal Immunology, 1–12. https://doi.org/10.1038/s41385-020-00359-2 Cite
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Treatment Strategies for Breast Cancer Brain Metastases

The authors provide an overview of the therapeutic option for brain metastases from breast cancer that is currently available and outlines potential new approaches for tackling these deadly secondary tumors.
[British Journal of Cancer]
Olah, M., Menon, V., Habib, N., Taga, M. F., Ma, Y., Yung, C. J., Cimpean, M., Khairallah, A., Coronas-Samano, G., Sankowski, R., Grün, D., Kroshilina, A. A., Dionne, D., Sarkis, R. A., Cosgrove, G. R., Helgager, J., Golden, J. A., Pennell, P. B., Prinz, M., … De Jager, P. L. (2020). Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease. Nature Communications, 11(1), 6129. https://doi.org/10.1038/s41467-020-19737-2 Cite
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The Emerging Role of miR‐128 in Musculoskeletal Diseases

Scientists discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.
[Journal of Cellular Physiology]
Shang, Q., Shen, G., Chen, G., Zhang, Z., Yu, X., Zhao, W., Zhang, P., Chen, H., Tang, K., Yu, F., Tang, J., Liang, D., Jiang, X., & Ren, H. (n.d.). The emerging role of miR-128 in musculoskeletal diseases. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30179 Cite
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Epigenetic Regulation in the Pathogenesis of Non-Melanoma Skin Cancer

The authors discuss the recent advances in the field of epigenetics of non-melanoma skin cancer. Particularly, the role of DNA methylation, histone hyperacetylation and non-coding RNA such as long-chain noncoding RNAs, circular RNAs and miRNA in the disease progression are summarized.
[Seminars in Cancer Biology]
Kashyap, M. P., Sinha, R., Mukhtar, M. S., & Athar, M. (2020). Epigenetic Regulation in the Pathogenesis of Non-melanoma Skin Cancer. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2020.11.009 Cite
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