Epigenetic Reprogramming of Cell Identity: Lessons from Development for Regenerative Medicine

Investigators highlight how gene regulatory mechanisms identified to be critical for developmental processes were successfully used for cellular reprogramming of various cell types.
[Clinical Epigenetics]
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SARS-CoV-2 Research Using Human Pluripotent Stem Cells and Organoids

Scientists summarize the latest results and issues of SARS-CoV-2 research using human ESC/iPSC-derived somatic cells and organoids.
[Stem Cells Translational Medicine]
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Harnessing Murine Models of Crohn’s Disease Ileitis to Advance Concepts of Pathophysiology and Treatment

The authors evaluate the mechanistic underpinnings of murine models of Crohn’s disease-ileitis, discuss their phenotypic similarities to human disease, and envisage their further exploitation for the development of novel targeted and personalized therapeutics.
[Mucosal Immunology]
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Exosomes in Atherosclerosis, a Double-Edged Sword: Their Role in Disease Pathogenesis and Their Potential as Novel Therapeutics

Scientists summarize the current understanding of exosome biogenesis and uptake, and discuss atherogenic and atheroprotective functions of exosomes secreted from these cell types.
[AAPS Journal]
Patel, N., Chin, D. D., & Chung, E. J. (2021). Exosomes in Atherosclerosis, a Double-Edged Sword: Their Role in Disease Pathogenesis and Their Potential as Novel Therapeutics. The AAPS Journal, 23(5), 95. https://doi.org/10.1208/s12248-021-00621-w Cite
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Pregnancy and Pandemics: Interaction of Viral Surface Proteins and Placenta Cells

Scientists display information on Variola, Influenza, Zika and Corona viruses focused on their surface proteins, effects on pregnancy, and possible target placental cells.
[Biochimica et Biophysica Acta]
Fuentes-Zacarías, P., Murrieta-Coxca, J. M., Gutierrez-Samudio, R. N., Schmidt, A., Schmidt, A., Markert, U. R., & Morales-Prieto, D. M. (2021). Pregnancy and pandemics: Interaction of viral surface proteins and placenta cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 166218. https://doi.org/10.1016/j.bbadis.2021.166218 Cite
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Arginine Depriving Enzymes: Applications as Emerging Therapeutics in Cancer Treatment

The L-Arginine (Arg) auxotrophic cancerous cells like hepatocellular carcinoma, human colon cancer, leukemia, and breast cancer cells were sensitive to Arg depriving enzymes treatment due to low expression of crucial enzymes argininosuccinate synthetase, argininosuccinate lyase, and ornithine transcarbamylase.
[Cancer Chemotherapy and Pharmacology]
Kumari, N., & Bansal, S. (2021). Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment. Cancer Chemotherapy and Pharmacology. https://doi.org/10.1007/s00280-021-04335-w Cite
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Engineering Bioactive Scaffolds for Skin Regeneration

The authors summarize the contribution of biomaterials to wound healing and skin regeneration and addresses the existing limitations in skin grafting.
[Small]
Hosseini, M., & Shafiee, A. (n.d.). Engineering Bioactive Scaffolds for Skin Regeneration. Small, n/a(n/a), 2101384. https://doi.org/10.1002/smll.202101384 Cite
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100 YEARS OF INSULIN: A Brief History of Diabetes Genetics: Insights for Pancreatic Beta-Cell Development and Function

Scientists explore the timeline and history of gene discovery and how this has coincided with progress in the fields of genomics.
[Journal of Endocrinology]
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Exploring the Regulatory Roles of Circular RNAs in the Pathogenesis of Atherosclerosis

The authors summarize the biogenesis, characteristics and functions of circRNAs with a focus on their roles in the pathogenesis of atherosclerosis.
[Vascular Pharmacology]
Sun, X., Deng, K., Zang, Y., Zhang, Z., Zhao, B., Fan, J., & Huang, L. (2021). Exploring the regulatory roles of circular RNAs in the pathogenesis of atherosclerosis. Vascular Pharmacology, 106898. https://doi.org/10.1016/j.vph.2021.106898 Cite
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Dendritic Cell Migration in Inflammation and Immunity

Investigators discuss the migratory routes and immunological consequences of distinct dendritic cell (DC) subsets, the molecular basis and regulatory mechanisms of migratory signaling in DCs, and the association of DC migration with the pathogenesis of autoimmune and infectious diseases.
[Cellular & Molecular Immunology]
Liu, J., Zhang, X., Cheng, Y., & Cao, X. (2021). Dendritic cell migration in inflammation and immunity. Cellular & Molecular Immunology, 1–11. https://doi.org/10.1038/s41423-021-00726-4 Cite
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Mucosal Vaccines – Fortifying the Frontiers

Mucosal vaccines offer the potential to trigger robust protective immune responses at the predominant sites of pathogen infection. The identification of safe and effective mucosal adjuvants allied to innovative antigen discovery and delivery strategies is key to advancing mucosal vaccines.
[Nature Reviews Immunology]
Lavelle, E. C., & Ward, R. W. (2021). Mucosal vaccines — fortifying the frontiers. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-021-00583-2 Cite
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