The authors compare genetics, microbiome, T‐cell infiltrate and resulting epithelial response in psoriasis and atopic dermatitis.
[Journal of Internal Medicine]
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Schäbitz, A., Eyerich, K., & Garzorz‐Stark, N. (n.d.). So close, and yet so far away: The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis. Journal of Internal Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/joim.13235 Cite
The ubiquitin proteasome system is a key regulatory factor in the proliferation, differentiation, and collagen secretion of skin fibroblasts.
[Molecular Diagnosis & Therapy]
The authors discuss the potential for genomic subtyping to improve prognostication and to help guide treatment selection. Thy summarize data on associations between androgen receptor (AR) pathway alterations and patient response to AR signaling inhibitors and other standards of care.
[Prostate Cancer and Prostatic Diseases]
Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
[Stem Cell Reviews and Reports]
Investigators review the possible roles of stem cell marker- or stemness-related genes in axon regeneration to gain a better understanding of the regeneration mechanism and to identify targets that can enhance regenerative capacity.
[Experimental and Molecular Medicine]
The authors summarize the literature, provide an approach to better understanding of the possible etiology of immune mediated cytopenias, and propose a diagnostic and management plan for patients with inherited metabolic disorders who develop single or multi-lineage cytopenias after hematopoietic stem cell transplantation.
[Bone Marrow Transplantation]
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Gupta, A. O., Jan Boelens, J., Ebens, C. L., Kurtzberg, J., Lund, T. C., Smith, A. R., Wagner, J. E., Wynn, R., Blazar, B. R., & Orchard, P. J. (2021). Consensus opinion on immune-mediated cytopenias after hematopoietic cell transplant for inherited metabolic disorders. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01179-5 Cite
The authors discuss how the view of the airway epithelial landscape has evolved with the advent of transcriptomic approaches to cellular phenotyping, with a focus on epithelial interactions with the local neuronal and immune systems.
[Nature Reviews Immunology]
Nature uses ECM scaffolds to organize biominerals into hierarchical structures over various length scales. This has inspired the design of biomimetic mineralization scaffolds, with DNA nanostructures being among the most promising. DNA nanotechnology makes use of molecular recognition to controllably give 1D, 2D and 3D nanostructures.
[Nature Reviews Chemistry]
Investigators introduce the development of induced pluripotent stem cells (iPSCs), the currently established iPSCs disease models, and artificial organoids related to neurodevelopmental impairments.
[International Journal of Medical Sciences]
Scientists examine the current knowledge of integrins’ role in breast cancer.
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Yousefi, H., Vatanmakanian, M., Mahdiannasser, M., Mashouri, L., Alahari, N. V., Monjezi, M. R., Ilbeigi, S., & Alahari, S. K. (2021). Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance. Oncogene, 1–21. https://doi.org/10.1038/s41388-020-01588-2 Cite
The authors summarize and focus on the recent discoveries of promising macromolecules and cell-based biomarkers for the diagnosis and prognosis of breast cancer and provide implications for therapeutic strategies.
[International Journal of Molecular Sciences]