Review

[Signal Transduction and Targeted Therapy] Scientists summarize the underlying mechanism, screening, diagnosis, prevention, and treatment of type 2 diabetes, especially regarding the personalized selection of hypoglycemic agents and holistic management based on the concept of metabolic syndrome-related target organ damage.

[Nature Reviews Molecular Cell Biology] Investigators discuss the diverse roles integrins have during cancer progression from cell migration across varied ECM landscapes to breaching barriers such as the basement membrane, and eventual colonization of distant organs.

[Cell Death Discovery] Scientists review the intrinsic mechanisms of tissue repair and remodeling via ferroptosis in different organs and systems under various conditions, including the inflammatory response in skin wounds, remodeling of joints and cartilage, and fibrosis in multiple organs.

[Nature Reviews Gastroenterology & Hepatology] Investigators discuss how different diets and metabolic changes influence intestinal stem cells in homeostatic and pathological conditions, as well as tumorigenesis.

[Blood] Investigators highlight ongoing efforts to identify reliable prognostic biomarkers and underscores the potential of genomics-based classification to guide future T-ALL treatment strategies.

[Journal of Clinical Investigation] The authors give an overview of the spectrum of clonal hematopoiesis driver mutations, what is known about their pathophysiology, and how this informs the risk of incident myeloid malignancy.