The authors focus on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies that can recover immune function, with a particular emphasis on approaches that can promote a diverse repertoire of T cells through de novo T cell formation.
[Nature Reviews Immunology]
Scientists explore how self-amplifying RNAs are emerging as important vaccine candidates for infectious diseases, the advantages of synthetic manufacturing approaches, and their potential for preventing and treating chronic infections.
The authors discuss the mechanisms exploited by Gram-positive bacteria to circumvent killing by antimicrobial peptides. Specifically, the most clinically relevant genera, Streptococcus spp., Staphylococcus spp., Enterococcus spp. and Gram-positive bacilli, have been explored.
[Frontiers in Microbiology]
6445218 HVDUSAMZ items 1 apa default asc 1
The authors present current knowledge on adipose stem and progenitor cells (ASPCs), their population structure, hierarchy, fat depot-specific nature, function, and regulatory mechanisms, and discuss not only the similarities, but also the differences between mouse and human ASPC biology.
[Trends in Cell Biology]
Investigators highlight major recent discoveries that illuminate the dynamics and cellular mechanisms that govern keratinocyte differentiation in the live mammalian skin and discuss the broader implications of these findings for our understanding of epithelial and stem cell biology in general.
[Current Opinion in Cell Biology]
The authors discuss how the recently defined functions of these Alzheimer’s disease (AD) risk genes can be targeted therapeutically to modulate microglial cell state and slow the progression of AD.
Scientists provide a short introduction on human and mouse neuronal migration processes, and highlight human brain organoid models of neuronal migration diseases.
[Current Opinion in Neurobiology]
The author provides a comprehensive picture of the progress using 3D in vitro culture models for extracellular vesicle analysis.
[Biotechnology and Bioengineering]
Organoid models offer new perspectives in personalized medicine and drug discovery. The authors discuss the current liver organoid models for the study of liver disease.
The authors focus on the regionally distinct lung epithelial cell types that contribute to repair after injury, and they address current controversies regarding whether elite stem cells or frequent facultative progenitors are the predominant participants.
[Annual Review of Physiology]
1254621 KBZ94RSY items 1 apa default asc 1
Alysandratos, K.-D., Herriges, M. J., & Kotton, D. N. (2021). Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration. Annual Review of Physiology, 83(1), null. https://doi.org/10.1146/annurev-physiol-041520-092904 Cite
Researchers bring together what is currently known about chromatin status and the development of cells in the hematopoietic system under normal and abnormal conditions.
[Trends in Genetics]