Review

[Blood] The authors discuss the history, preclinical studies, and successful translation of CD4+CD25+FoxP3+ Tregs in the context of allogeneic hematopoietic cell transplantation.

[Signal Transduction and Targeted Therapy] Scientists review the induction strategies of Tregs, covering various aspects including antigenic stimulation, cytokine modulation, metabolic pathways, epigenetic regulation, drug induction, and engineered technology.

[Nature] The authors highlight the state of the art of molecular and cellular mechanisms underlying metabolic dysfunction-associated steatohepatitis (MASH) pathogenesis and its transition to hepatocellular carcinoma.

[Gut] Scientists delineate the ferroptosis-immune axis in metabolic dysfunction-associated steatohepatitis (MASH) and establish a novel cell-type-specific transcriptomic framework governed by a core four-gene signature that maps the transition from early metabolic stress to advanced structural remodeling.

[Trends in Cancer] Scientists synthesize evidence that tumors become locked in either proinflammatory or pro-resolution phases, defined by neutrophil- or macrophage-dominated ecosystems.

[Cell Biomaterials] The authors summarize recent advances in recapitulating the ECM in organ-on-chip systems and argue that the next generation of organ-on-chip platforms will be defined not by increasing structural complexity alone but by their ability to integrate biologically instructive ECMs with manufacturable biomaterial systems.