The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

The emerging role of BMP signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature.
[International Journal of Molecular Sciences]
Ponomarev, L. C., Ksiazkiewicz, J., Staring, M. W., Luttun, A., & Zwijsen, A. (2021). The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology. International Journal of Molecular Sciences, 22(12), 6364. https://doi.org/10.3390/ijms22126364 Cite
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Not-So-Opposite Ends of the Spectrum: CD8+ T Cell Dysfunction across Chronic Infection, Cancer and Autoimmunity

A better understanding of these CD8+ T cell states may reveal novel strategies to augment clearance of chronic viral infection and cancer and to mitigate self-reactivity leading to tissue damage in autoimmunity.
[Nature Immunology]
Collier, J. L., Weiss, S. A., Pauken, K. E., Sen, D. R., & Sharpe, A. H. (2021). Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity. Nature Immunology, 1–11. https://doi.org/10.1038/s41590-021-00949-7 Cite
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Role of DAMPs in Respiratory Virus-Induced Acute Respiratory Distress Syndrome—with a Preliminary Reference to SARS-CoV-2 Pneumonia

The similar role of DAMPs is addressed, that is, of those molecules, which operate upstream of the inflammatory pathway by activating those cells, which ultimately release the cytokines.
[Genes & Immunity]
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Improving Antitumor Immunity Using Antiangiogenic Agents: Mechanistic Insights, Current Progress, and Clinical Challenges

The authors discuss synergies between antiangiogenic agents and cancer immunotherapy based on results from preclinical and translational studies.
[Cancer Communications]
Li, S.-J., Chen, J.-X., & Sun, Z.-J. (n.d.). Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges. Cancer Communications, n/a(n/a). https://doi.org/10.1002/cac2.12183 Cite
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Revisiting Steroidogenesis and Its Role in Immune Regulation with the Advanced Tools and Technologies

Investigators review the role of steroidogenesis in regulating inflammation and immunity, discuss the unresolved questions, and how this area can bring another golden age of steroid hormone research with the development of new tools and technologies and advancement of the scientific methods.
[Genes & Immunity]
Chakraborty, S., Pramanik, J., & Mahata, B. (2021). Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies. Genes & Immunity, 1–16. https://doi.org/10.1038/s41435-021-00139-3 Cite
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Therapeutic and Diagnostic Targeting of Fibrosis in Metabolic, Proliferative and Viral Disorders

Scientists discuss how anti-fibrotic therapies have progressed over the years, and how nanomedicine formulations can potentiate anti-fibrotic treatment efficacy.
[Advanced Drug Delivery Reviews]
Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders. (2021). Advanced Drug Delivery Reviews, 113831. https://doi.org/10.1016/j.addr.2021.113831 Cite
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Liver Organoids: Formation Strategies and Biomedical Applications

The authors summarize the formation strategies and a wide range of applications in biomedicine of liver organoid.
[Tissue Engineering and Regenerative Medicine]
Zhu, X., Zhang, B., He, Y., & Bao, J. (2021). Liver Organoids: Formation Strategies and Biomedical Applications. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-021-00357-w Cite
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Inflammation during Post-Injury Skeletal Muscle Regeneration

The authors present the interactions that leukocytes develop with the cells present in their vicinity, such as the activation of muscle stem cells and the maturation of newly formed myofibers, and the impact they have on skeletal muscle regeneration.
[Seminars in Cell & Developmental Biology]
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Inflammation as a Regulator of Hematopoietic Stem Cell Function in Disease, Aging, and Clonal Selection

Investigators review how major sources of systemic inflammation act on and subsequently shape HSCs fate and function. They highlight how lifelong inflammatory exposure contributes to HSC inflammatory-aging and selection of premalignant HSC clones.
[Journal of Experimental Medicine]
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Analyzing Signaling Activity and Function in Hematopoietic Cells

The authors discuss the requirements, potential, and limitations of the different current technologies for the analysis of hematopoietic stem and progenitor cell signaling and its effect on cell fates.
[Journal of Experimental Medicine]
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Stem Cells and Origins of Cancer in the Upper Gastrointestinal Tract

The authors discuss the biology of gastroesophageal stem cells and their role as cells of origin in cancer, and summarize the interactions between the stromal niche and gastroesophageal stem cells in metaplasia and early expansion of mutated stem-cell-derived clones during carcinogenesis.
[Cell Stem Cell]
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