Investigators highlight how gene regulatory mechanisms identified to be critical for developmental processes were successfully used for cellular reprogramming of various cell types.
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Scientists summarize the latest results and issues of SARS-CoV-2 research using human ESC/iPSC-derived somatic cells and organoids.
[Stem Cells Translational Medicine]
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The authors evaluate the mechanistic underpinnings of murine models of Crohn’s disease-ileitis, discuss their phenotypic similarities to human disease, and envisage their further exploitation for the development of novel targeted and personalized therapeutics.
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Scientists summarize the current understanding of exosome biogenesis and uptake, and discuss atherogenic and atheroprotective functions of exosomes secreted from these cell types.
Scientists display information on Variola, Influenza, Zika and Corona viruses focused on their surface proteins, effects on pregnancy, and possible target placental cells.
[Biochimica et Biophysica Acta]
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Fuentes-Zacarías, P., Murrieta-Coxca, J. M., Gutierrez-Samudio, R. N., Schmidt, A., Schmidt, A., Markert, U. R., & Morales-Prieto, D. M. (2021). Pregnancy and pandemics: Interaction of viral surface proteins and placenta cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 166218. https://doi.org/10.1016/j.bbadis.2021.166218 Cite
The L-Arginine (Arg) auxotrophic cancerous cells like hepatocellular carcinoma, human colon cancer, leukemia, and breast cancer cells were sensitive to Arg depriving enzymes treatment due to low expression of crucial enzymes argininosuccinate synthetase, argininosuccinate lyase, and ornithine transcarbamylase.
[Cancer Chemotherapy and Pharmacology]
The authors summarize the contribution of biomaterials to wound healing and skin regeneration and addresses the existing limitations in skin grafting.
Scientists explore the timeline and history of gene discovery and how this has coincided with progress in the fields of genomics.
[Journal of Endocrinology]
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The authors summarize the biogenesis, characteristics and functions of circRNAs with a focus on their roles in the pathogenesis of atherosclerosis.
Investigators discuss the migratory routes and immunological consequences of distinct dendritic cell (DC) subsets, the molecular basis and regulatory mechanisms of migratory signaling in DCs, and the association of DC migration with the pathogenesis of autoimmune and infectious diseases.
[Cellular & Molecular Immunology]
Mucosal vaccines offer the potential to trigger robust protective immune responses at the predominant sites of pathogen infection. The identification of safe and effective mucosal adjuvants allied to innovative antigen discovery and delivery strategies is key to advancing mucosal vaccines.
[Nature Reviews Immunology]