Neuroendocrine Control of Appetite and Metabolism

The authors discuss the regulation of appetite and metabolism by hypothalamic neurohormone-expressing cells, with a focus on the distinct contributions of neurohormones and neurotransmitters released by these neurons.
[Experimental & Molecular Medicine]
Yoo, E.-S., Yu, J., & Sohn, J.-W. (2021). Neuroendocrine control of appetite and metabolism. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-021-00597-9 Cite
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Astrocytes in Cocaine Addiction and Beyond

Scientists provide a brief overview of the role of astrocytes in regulating synaptic transmission and neuronal function, and discuss how cocaine influences these astrocyte-mediated mechanisms to induce persistent synaptic and circuit alterations that promote cocaine seeking and relapse.
[Molecular Psychiatry]
Wang, J., Holt, L. M., Huang, H. H., Sesack, S. R., Nestler, E. J., & Dong, Y. (2021). Astrocytes in cocaine addiction and beyond. Molecular Psychiatry, 1–17. https://doi.org/10.1038/s41380-021-01080-7 Cite
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Epithelial Sensing of Microbiota-Derived Signals

The authors highlight the pathways by which intestinal epithelial cells sense microbiota-derived signals and the necessity of these detection pathways in maintaining epithelial barrier integrity.
[Genes & Immunity]
Eshleman, E. M., & Alenghat, T. (2021). Epithelial sensing of microbiota-derived signals. Genes & Immunity, 1–10. https://doi.org/10.1038/s41435-021-00124-w Cite
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Systemic Immunity in Cancer

Emerging evidence suggests that immunotherapy drives new immune responses rather than the reinvigoration of pre-existing immune responses. Scientists comprehensively outline the current knowledge of systemic immunity in cancer.
[Nature Reviews Cancer]
Hiam-Galvez, K. J., Allen, B. M., & Spitzer, M. H. (2021). Systemic immunity in cancer. Nature Reviews Cancer, 1–15. https://doi.org/10.1038/s41568-021-00347-z Cite
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Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) has been shown to play a critical role in tumor development from initiation to metastasis. EMT could be regarded as a continuum, with intermediate hybrid epithelial and mesenchymal phenotypes having high plasticity.
[Clinical Cancer Research]
Taki, M., Abiko, K., Ukita, M., Murakami, R., Yamanoi, K., Yamaguchi, K., Hamanishi, J., Baba, T., Matsumura, N., & Mandai, M. (2021). Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4459 Cite
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Biological Nanotherapeutics for Liver Disease

Researchers discuss the cellular sources of EV, provide a concise overview of their potential use in diverse processes, and outline several promising applications for the use of EV based therapeutics for liver diseases.
[Hepatology]
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Use of Active Comparator Trials for Topical Medications in Dermatology

Some new medications may improve patient outcomes, others may not offer meaningful benefits vs existing less costly alternatives, especially in dermatology, in which subtle changes in the concentration or combination of topical agents can be classified as a novel product.
[JAMA Dermatology]
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The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

The authors disscuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.
[International Journal of Molecular Sciences]
Magatti, M., Masserdotti, A., Cargnoni, A., Papait, A., Stefani, F. R., Silini, A. R., & Parolini, O. (2021). The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy? International Journal of Molecular Sciences, 22(7), 3405. https://doi.org/10.3390/ijms22073405 Cite
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Durability of Immunity to SARS-CoV-2 and Other Respiratory Viruses

The authors summarize what is now known about adaptive immunity to SARS-CoV-2 and draw comparisons with immunity to other respiratory viruses, focusing on the longevity of protective responses.
[Trends in Microbiology]
Siggins, M. K., Thwaites, R. S., & Openshaw, P. J. M. (2021). Durability of immunity to SARS-CoV-2 and other respiratory viruses. Trends in Microbiology, 0(0). https://doi.org/10.1016/j.tim.2021.03.016 Cite
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The cGAS–STING Pathway as a Therapeutic Target in Inflammatory Diseases

Scientists outline the principal elements of the cGAS–STING signaling cascade and discuss the general mechanisms underlying the association of cGAS–STING activity with various autoinflammatory, autoimmune and degenerative diseases.
[Nature Reviews Immunology]
Decout, A., Katz, J. D., Venkatraman, S., & Ablasser, A. (2021). The cGAS–STING pathway as a therapeutic target in inflammatory diseases. Nature Reviews Immunology, 1–22. https://doi.org/10.1038/s41577-021-00524-z Cite
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Improving Outcomes in Chronic Myeloid Leukemia through Harnessing the Immunological Landscape

Scientists focus on immune dysfunction in newly diagnosed chronic myeloid leukemia patients, and the role that tyrosine kinase inhibitors and other therapies have in restoring immune surveillance.
[Leukemia]
Hsieh, Y.-C., Kirschner, K., & Copland, M. (2021). Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape. Leukemia, 1–14. https://doi.org/10.1038/s41375-021-01238-w Cite
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