The Hepatic Stellate Cells (HSTCs) and Adipose-Derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications

Researchers suggested that inter-organ communication on the level of stem progenitor cells-HSTCs and ASCs could represents a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity.
[Stem Cell Reviews and Reports]
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Liver Ischaemia–Reperfusion Injury: A New Understanding of the Role of Innate Immunity

Scientists summarize the role of macrophages, platelets and neutrophils in liver ischaemia–reperfusion injury (LIRI), highlight unanswered questions, and discuss prospects for innovative therapeutic regimens against LIRI in transplant recipients.
[Nature Reviews Gastroenterology & Hepatology]
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Extracellular Vesicles as a Source of Prostate Cancer Biomarkers in Liquid Biopsies: A Decade of Research

Prostate cancer is a global cancer burden and considerable effort has been made through the years to identify biomarkers for the disease. Investigators present the knowledge acquired during the last decade that constitutes a solid basis for the future development of liquid biopsy tests for prostate cancer.
[British Journal of Cancer]
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Non-Invasive Urine Metabolomics of Prostate Cancer and Its Therapeutic Approaches: A Current Scenario and Future Perspective

The authors provide a concise overview of the prostate cancer metabolomics-based potential discriminating molecules in urine samples using nuclear magnetic resonance spectroscopy and mass spectrometry.
[Expert Review of Proteomics]
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Minimally Invasive Treatments for Benign Prostatic Hyperplasia: A Cochrane Network Meta-Analysis

Scientists assess the comparative effectiveness and ranking of minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia.
[BJU International]
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Constructing a Cell Microenvironment with Biomaterial Scaffolds for Stem Cell Therapy

In recent years, emerging biomaterials that provide a supportable cellular microenvironment for transplanted cells have optimized the therapeutic efficacy of stem cells in injured tissues or organs.
[Stem Cell Research & Therapy]
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Mechanisms of Viral Inflammation and Disease in Humans

Single-gene inborn errors of cell-intrinsic or leukocytic immunity underlying diverse infections in the skin, brain, or lungs can help to clarify the human determinants of viral disease.
[Science]
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Castleman Disease

VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.
[Nature Reviews Disease Primers]
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Potential Role of Growth Factors Controlled Release in Achieving Enhanced Neuronal Trans-Differentiation from Mesenchymal Stem Cells for Neural Tissue Repair and Regeneration

The authors analyze the various carriers that have been employed for the release of growth factors in an orderly fashion and their constituents, along with the advantages and the limitations they pose in delivering the growth factors for facilitating the process of neuronal transdifferentiation.
[Molecular Neurobiology]
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Current Progress of Rehabilitative Strategies in Stem Cell Therapy for Spinal Cord Injury: A Review

Scientists summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of spinal cord injury.
[NPJ Regenerative Medicine]
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Addition of Immunotherapy to Chemotherapy for Metastatic Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

The authors conduct a meta-analysis, showing that the addition of programmed death-1/programmed death ligand-1 (PD-L1) blockade to chemotherapy improves progression-free survival in PD-L1 positive metastatic TNBC patients, also in the intention-to-treat population.
[Critical Reviews in Oncology Hematology]
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