Review

[Oncoimmunology] The authors underscore a dual role for B cells in melanoma, supporting antitumor immunity or promoting immune escape, and highlight opportunities to target regulatory B cells, correct isotype imbalance, and leverage B cell signatures as biomarkers.

[Genes and Immunity] Scientists provide a comprehensive analysis of the immune imbalance of allergic rhinitis, focusing on the key role of Th17/Treg cell imbalance in the pathogenesis of diseases.

[Mbio] Using the intestinal mucosa as a paradigm, scientists explore how the gut microenvironment fosters the generation of tolerogenic antigen-presenting cells and microbe-specific Tregs to enforce immunological tolerance.

[Nature Medicine] The authors highlight insights from recent clinical trials, translational studies and preclinical models, which reveal critical factors for optimizing cancer vaccines.

[Nature Reviews Immunology] The authors explore clinical and preclinical findings with cytokine-enhanced CAR T cells and discuss strategies for conditional cytokine secretion to mitigate systemic toxicity.

[Journal of Neuroinflammation] In amyotrophic lateral sclerosis, both Treg number and suppressive function decline, with remaining Tregs showing reduced FOXP3, the master transcription factor governing Treg function, expression and impaired regulatory capacity.