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How CBX Proteins Regulate Normal and Leukemic Blood Cells

[FEBS Letters] The authors describe how chromobox (CBX) proteins dictate age-related changes in HSCs and stimulate oncogenic HSC fate decisions, either as canonical polycomb repressive complex 1 members or by alternative interactions, including non-epigenetic regulation.

RNA m6A Methylation and Regulatory Proteins in Pulmonary Arterial Hypertension

[Hypertension Research] Scientists explored the mechanism and function of m6A in the pathogenesis of pulmonary arterial hypertension (PAH) and discuss the potential targeting of RNA m6A methylation modification as a treatment for PAH.

Emerging Strategies for Nanomedicine in Autoimmunity

[Advanced Drug Delivery Reviews] Investigators focus on leveraging the power of nanomedicine for prevalent autoimmune disorders throughout the body. They expand on three key areas for the development of autoimmunity therapies— avoiding systemic immunosuppression, balancing interactions with the immune system, and elevating current platforms for delivering complex cargoes.

CAR T Therapies in Multiple Myeloma: Unleashing the Future

[Cancer Gene Therapy] Ongoing preclinical and clinical trials are exploring the capabilities of CAR T cells in targeting specific antigens on myeloma cells, offering hope for patients with relapsed/refractory multiple myeloma.

Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix

[ACS Nano] Investigators focus on the regulatory role of nanomaterials in the process of cell synthesis of different ECM-related proteins and extracellular protease.

Liver Sinusoidal Endothelial Cell: An Important Yet Often Overlooked Player in the Liver Fibrosis

The authors update the various pathways by which liver sinusoidal endothelial cells are involved in the initiation and progression of liver fibrosis, including but not limited to cellular phenotypic change, the...