Review

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors dissect the “yin-yang” of BRAF as a therapeutic vulnerability in in melanoma and colorectal cancer and underscore the critical importance of tumor-specific context in precision oncology.

[Chinese Medical Journal] The authors analyze the complex role of growth differentiation factor 15 (GDF15) in various aspects of prostate cancer, including metabolism, chemoresistance, metastasis, and clinical implications.

[Journal of Mammary Gland Biology and Neoplasia] The authors shed light on the role of BRCA1 in lineage plasticity and highlights probable mechanisms by which BRCA1 could promote this lineage plasticity.

[Academic Radiology] The pathogenesis of vitiligo is centrally mediated by cytotoxic CD8+ T cells specific for melanocyte antigens and their production of IFN-γ. The involvement of other immune cells, such as resident memory T cells and regulatory T cells, innate immune cells,and non-immune cells including keratinocytes and fibroblasts have also garnered attention.

[Cell Death & Disease] The authors summarize the therapeutic potential of targeting ferroptosis pathways in tumor immunity, pathogen infections, inflammation, and autoimmune diseases.

[Nature Reviews Neurology] A deeper understanding of the multifaceted pathophysiology of Parkinson disease (PD)-associated cognitive impairment will help to explain the heterogeneity of cognitive profiles and disease progression in PD, providing a foundation for personalized disease-modifying treatments.