Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome

The authors focus on the therapeutic potential of mesenchymal stem/stromal cells (MSCs). MSCs are available from several tissues, including bone marrow, umbilical cord, and adipose tissue.
[Seminars in Respiratory and Critical Care Medicine]
Byrnes, D., Masterson, C. H., Artigas, A., & Laffey, J. G. (2020). Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome. Seminars in Respiratory and Critical Care Medicine. https://doi.org/10.1055/s-0040-1713422 Cite
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EMT-Inducing Transcription Factors, Drivers of Melanoma Phenotype Switching, and Resistance to Treatment

The authors present an update of the specific roles of EMT-TFs in melanocyte differentiation and melanoma progression. As major regulators of phenotype switching between differentiated/proliferative and neural crest stem cell-like/invasive states, these factors appeared as major drivers of intra-tumor heterogeneity.
[Cancers]
Tang, Y., Durand, S., Dalle, S., & Caramel, J. (2020). EMT-Inducing Transcription Factors, Drivers of Melanoma Phenotype Switching, and Resistance to Treatment. Cancers, 12(8), 2154. https://doi.org/10.3390/cancers12082154 Cite
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Synergy between Amyloid-β and Tau in Alzheimer’s Disease

The authors highlight the latest evidence base pertaining to the complex Aβ–tau interaction and underscore its crucial importance to elucidating disease pathogenesis and the design of next-generation Alzheimer’s disease therapeutic trials.
[Nature Neuroscience]
Busche, M. A., & Hyman, B. T. (2020). Synergy between amyloid-β and tau in Alzheimer’s disease. Nature Neuroscience, 1–11. https://doi.org/10.1038/s41593-020-0687-6 Cite
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Targeting Tumor‐Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies

Investigators propose a new vaccine platform that enhances all three arms of the adaptive immune system to improve tumor‐associated antigens‐based cancer vaccination in hepatocellular carcinoma patients.
[Hepatology]
Lu, L., Jiang, J., Zhan, M., Zhang, H., Wang, Q.-T., Sun, S.-N., Guo, X.-K., Yin, H., Wei, Y., Li, S.-Y., Liu, J. O., Li, Y., & He, Y.-W. (n.d.). Targeting Tumor-Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31502 Cite
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The Role of Mitochondrial Proteases in Leukemic Cells and Leukemic Stem Cells

Investigators highlight the functional consequences of inhibiting and activating mitochondrial proteases and discuss their potential as therapeutic targets in acute myeloid leukemia.
[Stem Cells Translational Medicine]
Mirali, S., & Schimmer, A. D. (n.d.). The role of mitochondrial proteases in leukemic cells and leukemic stem cells. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0142 Cite
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Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Look into Treatment Mechanism and Therapeutic Potential

Researchers show the transplantation protocol for mesenchymal stem cells (MSCs), discuss the potential therapeutic mechanisms, and summarize clinical trials on MSCs for treating ischemic stroke.
[Journal of Neurology]
Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J. (2020). Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential. Journal of Neurology. https://doi.org/10.1007/s00415-020-10138-5 Cite
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Exosomes — Beyond Stem Cells for Cardiac Protection and Repair

Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
[Stem Cells]
Balbi, C., & Vassalli, G. (n.d.). Exosomes — Beyond Stem Cells for Cardiac Protection and Repair. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3261 Cite
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Current Status and Future Perspectives of Checkpoint Inhibitor Immunotherapy for Prostate Cancer: A Comprehensive Review

Researchers review the current status of immunotherapy, including new discoveries and precision approaches to prostate cancer, and discuss future directions in the continuously evolving landscape of immunotherapy.
[International Journal of Molecular Sciences]
Kim, T. J., & Koo, K. C. (2020). Current Status and Future Perspectives of Checkpoint Inhibitor Immunotherapy for Prostate Cancer: A Comprehensive Review. International Journal of Molecular Sciences, 21(15), 5484. https://doi.org/10.3390/ijms21155484 Cite
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Immunological Distinctions between Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

The objective of this study was to differentiate the roles of specific immune cell subsets in nonalcoholic steatohepatitis and hepatocellular carcinoma pathogenesis.
[Experimental and Molecular Medicine]
Koo, S.-Y., Park, E.-J., & Lee, C.-W. (2020). Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-0480-3 Cite
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Hallmarks of Intestinal Stem Cells

The authors summarise the recent findings into how intestinal stem cell(ISC) identity can be defined by proliferation state, signalling crosstalk, epigenetics and metabolism, and propose an update on the hallmarks of ISCs. We further discuss how these properties contribute to intestinal development and the dynamics of injury-induced regeneration.
[Development]
Hallmarks of intestinal stem cells | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/147/15/dev182675.long Cite
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Antitumour Dendritic Cell Vaccination in a Priming and Boosting Approach

The authors believe that currently available strategies for vaccines that target dendritic cells or use them to present antitumour antigens could be integrated into existing clinical practice using prime–boost approaches.
[Nature Reviews Drug Discovery]
Harari, A., Graciotti, M., Bassani-Sternberg, M., & Kandalaft, L. E. (2020). Antitumour dendritic cell vaccination in a priming and boosting approach. Nature Reviews Drug Discovery, 1–18. https://doi.org/10.1038/s41573-020-0074-8 Cite
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Immunological Distinctions between Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

the liver is a central player in immunoregulation. Altered immune responses are tightly associated with the development of non-alcoholic steatohepatitis and hepatocellular carcinoma.
[Experimental and Molecular Medicine]
Koo, S.-Y., Park, E.-J., & Lee, C.-W. (2020). Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-0480-3 Cite
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