Review

[Expert Opinion on Therapeutic Targets] The authors review the metabolic strategies that HER2⁺ breast cancer cells adopt to enable trastuzumab resistance, grouping them into a structured classification that takes into account their functional nature, namely: (1) metabolic reprogramming; (2) adaptive stress response; and (3) metabolic-signaling crosstalk.

[Journal for Immunotherapy of Cancer] The authors provide a comprehensive overview of tumor organoid generation, their characteristics, and their use as models to study tumor-immune interactions.

[Trends In Neurosciences] Transcriptional regulation enables neuron-wide structural adaptations, while synapse-specific transport and maturation ensure localized protein synthesis.

[NPJ Aging ] Scientists provide an overview of how Rab3s dysregulation disrupts neuronal homeostasis, contributing to impaired autophagy, synaptic dysfunction, and eventually leading to neuronal death.

[Journal of Clinical Investigation] The author examines how tumor-stroma crosstalk mechanisms shape metastatic progression in PDAC and provides a framework for understanding why conventional therapies often fail against metastatic disease.

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors provide a comprehensive and comparative investigation of circulating tumour cells/circulating tumour microemboli biology, highlight recent advancements in their isolation and detection technologies, and underline their growing role along with associated challenges in oncology and clinical management.