Review

[Nature Reviews Endocrinology] The authors review established and emerging cellular mechanisms of insulin resistance, their complex integrative features and their relevance to disease progression.

[Translational Neurodegeneration] The authors summarize the main strategies and techniques of current ALS gene therapies based on ALS risk genes, and review recent findings from animal studies and clinical trials.

[Molecular Cancer] The authors depict the lung susceptibility and the molecular profiles of tumors with the potential for lung metastasis.

[Advanced Drug Delivery Reviews] Cell-based therapies using iPSCs or ESCs offer potential solutions for restoring damaged retinal cells. The authors summarize recent advances in retinal pigment epithelium and photoreceptor cells transplantation, highlighting the benefits of each approach.

[Leukemia] The authors review recent evidence showing that OCT4 expressed in cancer stem cells plays a multifaceted role in shaping the TME by interacting with the cellular TME components, including cancer-associated fibroblasts, tumor endothelial cells, tumor-infiltrating immune cells, as well as the non-cellular TME components, such as ECM.

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors summarize recent findings from patient samples and mouse models of breast cancer, focusing on gene signatures identified by single-cell RNA sequencing that define cancer-associated fibroblast subtypes and predict cancer prognosis.