So Close, and Yet So Far Away: The Dichotomy of the Specific Immune Response and Inflammation in Psoriasis and Atopic Dermatitis

The authors compare genetics, microbiome, T‐cell infiltrate and resulting epithelial response in psoriasis and atopic dermatitis.
[Journal of Internal Medicine]
Schäbitz, A., Eyerich, K., & Garzorz‐Stark, N. (n.d.). So close, and yet so far away: The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis. Journal of Internal Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/joim.13235 Cite
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The Ubiquitin Proteasome System and Skin Fibrosis

The ubiquitin proteasome system is a key regulatory factor in the proliferation, differentiation, and collagen secretion of skin fibroblasts.
[Molecular Diagnosis & Therapy]
Shen, W., Zhang, Z., Ma, J., Lu, D., & Lyu, L. (2021). The Ubiquitin Proteasome System and Skin Fibrosis. Molecular Diagnosis & Therapy. https://doi.org/10.1007/s40291-020-00509-z Cite
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Clinical Implications of Genomic Alterations in Metastatic Prostate Cancer

The authors discuss the potential for genomic subtyping to improve prognostication and to help guide treatment selection. Thy summarize data on associations between androgen receptor (AR) pathway alterations and patient response to AR signaling inhibitors and other standards of care.
[Prostate Cancer and Prostatic Diseases]
Sumiyoshi, T., Chi, K. N., & Wyatt, A. W. (2021). Clinical implications of genomic alterations in metastatic prostate cancer. Prostate Cancer and Prostatic Diseases, 1–13. https://doi.org/10.1038/s41391-020-00308-x Cite
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Advances in Liver Cancer Stem Cell Isolation and their Characterization

Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
[Stem Cell Reviews and Reports]
Liu, L., & Borlak, J. (2021). Advances in Liver Cancer Stem Cell Isolation and their Characterization. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10114-6 Cite
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Potential Roles of Stem Cell Marker Genes in Axon Regeneration

Investigators review the possible roles of stem cell marker- or stemness-related genes in axon regeneration to gain a better understanding of the regeneration mechanism and to identify targets that can enhance regenerative capacity.
[Experimental and Molecular Medicine]
Lee, J., & Cho, Y. (2021). Potential roles of stem cell marker genes in axon regeneration. Experimental & Molecular Medicine, 1–7. https://doi.org/10.1038/s12276-020-00553-z Cite
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Consensus Opinion on Immune-Mediated Cytopenias after Hematopoietic Cell Transplant for Inherited Metabolic Disorders

The authors summarize the literature, provide an approach to better understanding of the possible etiology of immune mediated cytopenias, and propose a diagnostic and management plan for patients with inherited metabolic disorders who develop single or multi-lineage cytopenias after hematopoietic stem cell transplantation.
[Bone Marrow Transplantation]
Gupta, A. O., Jan Boelens, J., Ebens, C. L., Kurtzberg, J., Lund, T. C., Smith, A. R., Wagner, J. E., Wynn, R., Blazar, B. R., & Orchard, P. J. (2021). Consensus opinion on immune-mediated cytopenias after hematopoietic cell transplant for inherited metabolic disorders. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01179-5 Cite
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Regulation of Immune Responses by the Airway Epithelial Cell Landscape

The authors discuss how the view of the airway epithelial landscape has evolved with the advent of transcriptomic approaches to cellular phenotyping, with a focus on epithelial interactions with the local neuronal and immune systems.
[Nature Reviews Immunology]
Hewitt, R. J., & Lloyd, C. M. (2021). Regulation of immune responses by the airway epithelial cell landscape. Nature Reviews Immunology, 1–16. https://doi.org/10.1038/s41577-020-00477-9 Cite
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DNA Nanostructures as Templates for Biomineralization

Nature uses ECM scaffolds to organize biominerals into hierarchical structures over various length scales. This has inspired the design of biomimetic mineralization scaffolds, with DNA nanostructures being among the most promising. DNA nanotechnology makes use of molecular recognition to controllably give 1D, 2D and 3D nanostructures.
[Nature Reviews Chemistry]
Athanasiadou, D., & Carneiro, K. M. M. (2021). DNA nanostructures as templates for biomineralization. Nature Reviews Chemistry, 1–16. https://doi.org/10.1038/s41570-020-00242-5 Cite
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Great Expectations: Induced Pluripotent Stem Cell Technologies in Neurodevelopmental Impairments

Investigators introduce the development of induced pluripotent stem cells (iPSCs), the currently established iPSCs disease models, and artificial organoids related to neurodevelopmental impairments.
[International Journal of Medical Sciences]
Zhang, X., Li, Z., Liu, Y., & Gai, Z. (2021). Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments. International Journal of Medical Sciences, 18(2), 459–473. https://doi.org/10.7150/ijms.51842 Cite
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Understanding the Role of Integrins in Breast Cancer Invasion, Metastasis, Angiogenesis, and Drug Resistance

Scientists examine the current knowledge of integrins’ role in breast cancer.
[Oncogene]
Yousefi, H., Vatanmakanian, M., Mahdiannasser, M., Mashouri, L., Alahari, N. V., Monjezi, M. R., Ilbeigi, S., & Alahari, S. K. (2021). Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance. Oncogene, 1–21. https://doi.org/10.1038/s41388-020-01588-2 Cite
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Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer

The authors summarize and focus on the recent discoveries of promising macromolecules and cell-based biomarkers for the diagnosis and prognosis of breast cancer and provide implications for therapeutic strategies.
[International Journal of Molecular Sciences]
Wu, H.-J., & Chu, P.-Y. (2021). Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer. International Journal of Molecular Sciences, 22(2), 636. https://doi.org/10.3390/ijms22020636 Cite
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