Autoreactive Napsin A–Specific T Cells Are Enriched in Lung Tumors and Inflammatory Lung Lesions during Immune Checkpoint Blockade

In patients with non-small cell lung cancer treated with immune checkpoint blockade (ICB), napsin A was a self-antigen that elicited strong CD8+ T cell responses, with ICB responders harboring higher frequencies of these CD8+ T cells compared with nonresponders.