TREM2/β-Catenin Attenuates NLRP3 Inflammasome-Mediated Macrophage Pyroptosis to Promote Bacterial Clearance of Pyogenic Bacteria

The authors demonstrated that deficiency of triggering receptors expressed on myeloid cells 2 (TREM2) significantly enhanced macrophage pyroptosis induced by four common pyogenic bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae, and Escherichia coli.