The cAMP/PKA/CREB and TGF-β/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells

Investigators revealed the essential roles of ALCAM and PROM1, as well as their upstream regulators, the cAMP/PKA/CREB and TGF-β/SMAD4 pathways, in maintaining the stemness and metastatic potential of colorectal cancer cells.