Distinct Cellular Dynamics Associated with Response to CAR-T Therapy for Refractory B Cell Lymphoma

Investigators performed single-cell transcriptome sequencing of 105 pretreatment and post-treatment peripheral blood mononuclear cell samples, and infusion products collected from 32 individuals with large B cell lymphoma treated with either of two CD19 CAR-T products: axicabtagene ciloleucel or tisagenlecleucel .