Anti-CD19 Car T Cell Therapy for Refractory Systemic Lupus Erythematosus

Autologous T cells from patients with systemic lupus erythematosus were transduced with a lentiviral anti-CD19 CAR vector, expanded and reinfused at a dose of 1 × 106 CAR T cells per kilogram of body weight into the patients after lymphodepletion with fludarabine and cyclophosphamide.