Elevating Microglia TREM2 Reduces Amyloid Seeding and Suppresses Disease-Associated Microglia

By using microglia-specific inducible mouse models overexpressing human wild-type TREM2 (TREM1-WT) or R47H risk variant, scientists showed that TREM2-WT expression reduced amyloid deposition and neuritic dystrophy only during the early amyloid seeding stage