Newsletters

[DHMC] The National Emerging Special Pathogens Training and Education Center recently awarded Dartmouth Health’s Dartmouth Hitchcock Medical Center (DHMC) a $500,000 grant to build its capabilities as a Level 2 Special Pathogen Treatment Center.

[Model Medicines] Model Medicines announced preclinical data demonstrating that MDL-001 has potent antiviral activity against both hepatitis C virus (HCV) and hepatitis B virus (HBV). These results establish preclinical proof of concept for a single non-nucleoside agent targeting HCV/HBV co-infection.

[Nature Immunology] Scientists found that a universal feature of tuberculosis granulomas is partitioning of the myeloid core into two distinct metabolic environments, one of which is hypoxic.

[Nature Microbiology] Researchers used immunopeptidomics to identify CD4+ T cell vaccine targets in methicillin-resistant Staphylococcus aureus.

[Cellular & Molecular Immunology] Using a murine cytomegalovirus infection model, investigators demonstrated that B cell-deficient mice mounted a weaker primary virus-specific CD8+ T-cell response than their wild-type counterparts did, which was associated with increased viral transcription.

[Cellular & Molecular Biology Letters] Certain viruses evolve mechanisms for inhibiting autophagy, enabling evasion of degradation and immune detection, since autophagy is frequently related to inflammatory diseases, including infections, autoimmune disorders, cancer, neurodegenerative conditions, and cardiovascular and liver diseases.

[Proceedings of the National Academy of Sciences of the United States of America] Epstein–Barr virus and Kaposi’s sarcoma–associated herpesvirus, both known to drive various malignancies, were observed to induce Never in mitosis A (NIMA)-related kinase 2 (NEK2) expression during both primary infection and latent phases of infection.

[Signal Transduction and Targeted Therapy] The authors present a comprehensive timeline detailing the development of antiviral drugs, tracing the progression from early viral inhibitors to modern broad-spectrum antiviral agents.

[Journal of Nanobiotechnology] Scientists demonstrated that plant-derived exosome-like nanoparticles represent a novel and effective nanotherapeutic strategy for lymphedema by orchestrating metabolic reprogramming and inhibiting fibrosis.

[Journal of Translational Medicine] Investigators identified a Piezo1/Yes-associated protein 1 (YAP1)/glutaminase 1 (GLS1) axis linking mechanical stress to metabolic reprogramming and fibroblast activation in bladder outlet obstruction, which may serve as a therapeutic target to prevent fibrosis and preserve bladder function.

[American Journal of Respiratory Cell and Molecular Biology] Researchers showed that fibroblast growth factor 2 stimulated proliferation and expression of various fibrotic markers in human pulmonary fibroblasts from healthy donors and idiopathic pulmonary fibrosis patients.

[Scientific Reports] Researchers investigated cell adhesion molecule 1 (CADM1) function in connective tissue mast cells (CTMCs) using a monoclonal antibody against the extracellular domain of CADM1, termed 3E1.