Newsletters

[Everest Medicines] Everest Medicines announced that China's National Medical Products Administration (NMPA) has approved VELSIPITY^® for the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response, lost response, or were intolerant to either conventional therapy or a biologic agent.

[Cell Discovery] Researchers identified palmitic acid as a metabolite cue that activates c-Myc via dual palmitoylation-dependent pathways operating across tumor initiation and progression.

[Gut] Investigators elucidated the role of Acinetobacter baumannii in enhancing nicotinamide adenine dinucleotide (NAD) metabolism in gastric cancer (GC) cells through NA synthesis, consequently promoting GC metastasis.

[Gut] Scientists aimed to develop mouse models of sporadic and hereditary diffuse gastric cancer (DGC) by inactivation of Cdh1 in the mouse stomach. They generated tamoxifen-inducible Cre/loxP mouse models of DGC driven by the Cd44 promoter with a tdTomato reporter.

[Science Advances] Researchers identified elongation of very-long-chain fatty acid protein 6 (Elovl6) as a critical regulator in colorectal cancer progression. Clinical data reveal significant down-regulation of Elovl6 in colon cancer tissues.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that MAPKAPK2 protein levels in colorectal carcinoma regulate cell fate decision during stress conditions, such as glucose deprivation and therapeutic treatment.

[Experimental & Molecular Medicine] By leveraging single-cell and bulk transcriptome data, scientists demonstrated that neddylation is associated with G2M phase progression in colorectal cancer (CRC). They identified ubiquitin conjugating enzyme E2 M (UBE2M) as a molecular bridge spanning neddylation and the cell cycle in CRC.

[Iscience] The authors demonstrated that the human hydroxyacyl-CoA dehydrogenase gene, catalyzing the third step of the mitochondrial β-oxidation cascade, has two alternative translation start codons.

[Scientific Reports] Researchers identified a significant upregulation of PLOD2 in colorectal cancer (CRC). This upregulation was closely associated with clinical stage, lymph node metastasis, and nerve invasion in CRC.

[Current Allergy and Asthma Reports] The authors summarize the current understanding of antigen transport across the intestinal epithelium in steady state and food-allergic conditions.

[Proceedings of the National Academy of Sciences of the United States of America] Multipronged data on a complementary pair of murine metabolic-dysfunction-associated steatohepatitis (MASH) models and published single-cell RNA-sequencing datasets from MASH patients revealed a critical protective role for Foxp3+CD4+ Tregs in MASH.

[Nature Communications] Scientists assessed a Vδ1 + γδ T cell-based adoptive cell therapy, named Delta One T cells, to treat cytomegalovirus infection in high-risk transplant recipients.