Chemotherapy-Induced Complement Signaling Modulates Immunosuppression and Metastatic Relapse in Breast Cancer

Researchers showed that systemic treatment with doxorubicin, but not cisplatin, following resection of a TNBC tumor induceD the expression of complement factors in lung fibroblasts, and modulateD an immunosuppressive metastatic niche that supported lung metastasis.