HK1 from Hepatic Stellate Cell–Derived Extracellular Vesicles Promotes Progression of Hepatocellular Carcinoma

Scientists demonstrated that in hepatic fibrosis, TGF-β stimulated the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells, which facilitated the secretion of HK1 via large extracellular vesicles in a TSG101-dependent manner.