Bip-Yorkie Interaction Determines Oncogenic and Tumor-Suppressive Roles of Ire1/Xbp1s Activation

In human TNBC cell lines and xenograft models, ectopic XBP1s or HSPA5 expression alleviated tumor growth but aggravated cell migration and invasion. These findings uncovered a conserved crosstalk between the Ire1/Xbp1s and Hippo signaling pathways under physiological settings, as well as a crucial role of Bip-Yki interaction in tumorigenesis that is shared from Drosophila to humans.