Lipid Droplet Turnover at the Lysosome Inhibits Growth of Hepatocellular Carcinoma in a BNIP3-Dependent Manner

Low BNIP3 expression in human HCC correlated with increased lipid content and worse prognosis than HCC expressing high BNIP3. BNIP3 suppressed HCC cell growth by promoting lipid droplet turnover at the lysosome in a manner dependent on BNIP3 binding LC3.