Emergence of Highly Profibrotic and Proinflammatory Lrat⁺Fbln2⁺ Hepatic Stellate Cell Subpopulation in Alcoholic Hepatitis

Lrat+Fbln2+ cells had 3-15x inductions of profibrotic, myofibroblastic and immunoregulatory genes vs. Lrat+Fbln2– cells, but 2-4x repressed hepatic stellate cell-selective genes.