Inhibition of Mps1 Kinase Enhances Taxanes Efficacy in Castration Resistant Prostate Cancer

Researchers explored the possibility of forced mitotic exit to elevate Taxane efficacy. Inactivation of the SAC component, mitotic checkpoint kinase Mps1/TTK with a small molecule inhibitor (Msp1i), potentiated efficacy of Taxanes treatment in both 2D cell culture and 3D prostasphere settings.