A Cryptic Transactivation Domain of EZH2 Binds AR and AR’s Splice Variant, Promoting Oncogene Activation, and Tumorous Transformation

Scientists reported that a cryptic transactivation domain of EZH2 binds both androgen receptor (AR) and AR spliced variant 7 mediating assembly and/or recruitment of transactivation-related machineries at genomic sites that lack polycomb repressive complex 2 binding.