Metformin Alleviates HFD-Induced Oxidative Stress in Hepatocyte via Activating SIRT6/PGC-1α/ENDOG Signaling

By taking advantage of mouse model of high-fat-diet-induced (HFD) obesity and primary mouse hepatocytes as well as human hepatocyte L02 cell line, the authors investigated the involvement of SIRTs during the application of metformin for the therapy of type 2 diabetes.