Targeted Activation of HNF4α/HGF1/FOXA2 Reverses Hepatic Fibrosis via Exosome-Mediated Delivery of CRISPR/dCas9-SAM System

The authors constructed a modified-exosome delivery system targeting hepatic stellate cells (HSCs), and constructed the CRISPR/dCas9-SAM system inducing HSCs convert into hepatocyte-like cells in vitro and in vivo.