Newsletters

[Signal Transduction and Targeted Therapy] Integrating single-cell level imaging analyses with mechanistic studies, preclinical therapeutic experiments, and a Phase Ib clinical trial, scientists elucidated the AR+/-BCL-2+/- prosate cancer cell subpopulation dynamics and positioned BCL-2 as a therapeutic target in heterogeneous CRPC.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed Ad5-Envp- virus-like particles (VLP,) a chimeric adenoviral platform enabling spontaneous in vivo assembly of envelope protein-displaying VLPs using advanced technology. Intranasal administration of a single-dose Ad5-HA-VLP confers long-lasting protection against influenza A strains.

[Nature Reviews Gastroenterology & Hepatology] The authors present basic features of γδ T cells and their distribution and function in the context of the local immune response. Given their cytotoxic activity and HLA-independent mode of action, there is increasing interest in harnessing γδ T cells for application in cancer immunotherapy.

[Nature] Researchers showed that the short-term nutritional state of an individual has marked effects on T cell immunity. Human or murine T cells from fed hosts had higher metabolic capacity than those from fasted hosts, and this increase in capacity persisted after activation and expansion in vitro or in vivo.

[JCI Insight] Investigators performed a randomized, placebo-controlled nicotinamide riboside-supplementation study in individuals with mild-to-moderate psoriasis.

[Immunity] Single-cell RNA sequencing of plasmacytoid dendritic cells (pDCs) from blood, thymus, lymph nodes, and tonsils across fetal, infant, and pediatric stages revealed tissue-enriched programs, including IFN-I-imprinted pDCs in the thymus, NF-κB-imprinted pDCs in tonsils, and resting pDCs in blood and lymph nodes.

[Science Translational Medicine] Investigators designed intranasally administered, live-attenuated influenza vaccine to stimulate mucosal immunity. They examined human mucosal and systemic immunity after seasonal intramuscular or intranasal vaccination.

[Nature] Investigators identified a vaccination strategy using heterologous HIV envelope glycoprotein trimers covalently coupled to liposomes for multivalent display that resulted in the elicitation of cross-neutralizing HIV serum antibody responses in all trimer-liposome-immunized non-human primates.

[Microbiology Spectrum] The authors explored the effect of uterine natural killer cells on uterine injury in a dengue virus (DENV)-induced adverse pregnancy mouse model. Transcriptomic analysis revealed significant dysregulation of uterine vascular remodeling and immune response-related gene expression after DENV-2 infection.

[Cellular & Molecular Immunology] Researchers developed a disulfide-substituted T cell receptor (TCR), in which the native disulfide bond is replaced with artificially designed disulfide bonds within constant domains to increase the fidelity and functionality of TCR pairing.

[Nature Microbiology] Recent advances enable high-resolution studies to be performed at scale in bacteria, yielding fundamental insights into how heterogeneity influences bacterial physiology, metabolism, antibiotic resistance, pathogenesis and interactions within complex microbial communities.

[Nature Biotechnology] Scientists reprogrammed Cas12a into a DNA-guided, RNA-targeting effector. Exploiting protospacer-adjacent motif-dependent interaction, they engineered synthetic CRISPR DNA that engages Cas12a to form a functional deoxyribonucleoprotein complex, while repurposing solely RNA as the programmable target.