Newsletters

[University of Maryland Baltimore] The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center is the first in the Maryland, Delaware, Virginia, and Washington, D.C., region to offer a cell therapy treatment for patients with an advanced type of soft tissue cancer, known as synovial sarcoma.

[Oncology News Central] The US FDA has fully approved afamitresgene autoleucel and expanded its indication to include patients aged 12 years and older with unresectable or metastatic synovial sarcoma whose disease has progressed after chemotherapy.

[Nature Communications] Researchers performed comprehensive multi-omic profiling of an unselected perivascular epithelioid cell neoplasm cohort. Transcriptomic analysis defined four subtypes with distinct lineage programs—melanocytic, mesenchymal, or adipogenic—as well as unique mutational patterns and clinical behaviors.

[International Immunopharmacology] In the past 20 years, MSCs have emerged as attractive treatment options for osteoporosis due to their capacity to differentiate into osteoblasts, modulate immune responses, and exert paracrine effects.

[Scientific Reports] Researchers confirmed that leptin-induced autophagy regulated the immunomodulatory potential of adipose-derived MSCs through downregulating the expression of TSG-6 via the activation of p38 pathway.

[Cancer Gene Therapy] Scientists investigated the use of tumor-homing MSCs as retroviral replicating vectors carriers in a clinically relevant model of malignant peritoneal mesothelioma.

[Inflammation and Regeneration] Scientists hypothesized that restoring MOTS-c signaling rescues the impaired functionality of adipose-derived MSCs from individuals with obesity.

[Stem Cell Research & Therapy] Researchers focused on amnion-derived MSCs, which can be obtained non-invasively after delivery, and investigated their therapeutic effects in a rat model of anti-glomerular basement membrane nephritis.

[Stem Cell Research & Therapy] Scientists demonstrated that caveolin-1 (CAV1) enhances mitochondrial transfer from human umbilical-cord-derived MSCs to injured epithelial cells.

[Nature] In humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, researchers demonstrated mutation-dependent responses to sleep and exercise in clonal haematopoiesis and showed that mutant cells are uniquely sensitive to lifestyle.

[Blood] Scientists identified METTL1 as a key regulator of leukemia stem cell self-renewal and homing within bone marrow microenvironment through catalyzing m⁷G formation on a specific tRNA, tRNA^Phe_GAA, thereby promoting leukemogenesis.

[Cell Death & Disease] Researchers found that multiple lipid metabolism processes are aberrantly activated in Ara-C resistant AML cells, accompanied by upregulation of JAK-STAT3 signaling and key lipid metabolic regulators, notably SREBP1 and CPT2.