Tumor and Stroma COL8A1 Secretion Induces Autocrine and Paracrine Progression Signaling in Pancreatic Ductal Adenocarcinoma

Scientists identified collagen type VIII alpha 1 chain (COL8A1) expression in seven examined PDAC cell lines by microarray analysis, western blotting, and RT‒qPCR. Higher COL8A1 expression occurred in 2 gemcitabine-resistant PDAC cell lines.