EZH2-H3K27me3 Mediated KRT14 Upregulation Promotes TNBC Peritoneal Metastasis

Researchers revealed that selective hyper-activation of functional enhancer of zeste homolog 2 (EZH2) (H3K27me3) over non-catalytic EZH2 altered TNBC metastatic landscape and fostered its peritoneal metastasis, particularly splenic.