PRDM1/BLIMP1 Induces Cancer Immune Evasion by Modulating the USP22-SPI1-PD-L1 Axis in Hepatocellular Carcinoma Cells

Tumoral Prdm1 overexpression upregulated PD-L1 levels, dampening anti-tumor immunity in vivo, and neutralized the anti-tumor efficacy of Prdm1 overexpression in immune-competent mouse models.