Mechanistic Target of Rapamycin Complex 1 Orchestrates the Interplay between Hepatocytes and Kupffer Cells to Determine the Outcome of Immune-Mediated Hepatitis

Scientists dissected the impact of activated mTORC1 on the cell-cell interaction of Kupffer cells (KCs) and hepatocyte in immune-mediated hepatitis. In the liver from patients with AIH and mice administrated with Con-A, mTORC1 was activated in both KCs and hepatocytes.