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Investigators described the derivation of syngeneic induced pluripotent stem cells (iPSCs) engineered to determine the effects of Z alpha-1 antitrypsin heterozygosity in iPSC-hepatocytes.
[Cell Reports]
Human iPSC-Hepatocyte Modeling of Alpha-1 Antitrypsin Heterozygosity Reveals Metabolic Dysregulation and Cellular Heterogeneity
