Intracellular Deposits of Amyloid-Beta Influence the Ability of Human iPSC-Derived Astrocytes to Support Neuronal Function

The authors aimed to investigate how intracellular deposits of Aβ in astrocytes affected their interplay with neurons, focusing on neuronal function and viability. For this purpose, human induced pluripotent stem cell (hiPSC)-derived astrocytes were exposed to sonicated Αβ42 fibrils.