Hesperidin Methylchalcone (HMC) Hinders Amyloid-β Induced Alzheimer’s Disease by Attenuating Cholinesterase Activity, Macromolecular Damages, Oxidative Stress and Apoptosis via Regulating NF-κB and Nrf2/HO-1 Pathways

The protective effect of hesperidin methylchalcone was evaluated through Alzheimer’s disease models of Neuro-2a cells and Wistar rats. The in vitro results showed that HMC possessed a significant ability to inhibit the acetylcholinesterase enzyme and exhibited anti-aggregation and disaggregation properties.