Small CD4 Mimetics Sensitize HIV-1-Infected Macrophages to Antibody-Dependent Cellular Cytotoxicity

The authors used monocyte-derived macrophages as a model to better understand the role of HIV-1 Nef, Vpu, and Env on CD4 downregulation in this cell type, and studied how this impacts Env conformation and susceptibility to antibody-dependent cellular cytotoxicity.